Dual personality of memory T cells
نویسندگان
چکیده
منابع مشابه
Self-restricted dual receptor memory T cells.
Enhanced immune responses during secondary exposure to Ag result from the development of memory cells. In the present report we show that stimulation through one receptor on dual receptor CD4 cells can promote the generation of T cells capable of giving a memory response through the second receptor, even though the cells had not been previously exposed to the Ag recognized by the second recepto...
متن کاملT-dual Rickart modules
We introduce the notions of T-dual Rickart and strongly T-dual Rickart modules. We provide several characterizations and investigate properties of each of these concepts. It is shown that every free (resp. finitely generated free) $R$-module is T-dual Rickart if and only if $overline{Z}^2(R)$ is a direct summand of $R$ and End$(overline{Z}^2(R))$ is a semisimple (resp. regular) ring. It is sho...
متن کاملThe dual role of IL-2 in the generation and maintenance of CD8+ memory T cells.
The mechanisms responsible for the generation and maintenance of T cell memory are unclear. In this study, we tested the role of IL-2 in allospecific CD8+ T cell memory by analyzing the long-term survival, phenotype, and functional characteristics of IL-2-replete (IL-2+/+) and IL-2-deficient (IL-2-/-) CD8+ TCR-transgenic lymphocytes in an adoptive transfer model. We found that IL-2 is not essen...
متن کاملDual Role of miR-21 in CD4+ T-Cells: Activation-Induced miR-21 Supports Survival of Memory T-Cells and Regulates CCR7 Expression in Naive T-Cells
Immune cell-type specific miRNA expression patterns have been described but the detailed role of single miRNAs in the function of T-cells remains largely unknown. We investigated the role of miR-21 in the function of primary human CD4+ T-cells. MiR-21 is substantially expressed in T-cells with a memory phenotype, and is robustly upregulated upon αCD3/CD28 activation of both naive and memory T-c...
متن کاملMemory T Follicular Helper CD4 T Cells
T follicular helper (Tfh) cells are the subset of CD4 T helper cells that are required for generation and maintenance of germinal center reactions and the generation of long-lived humoral immunity. This specialized T helper subset provides help to cognate B cells via their expression of CD40 ligand, IL-21, IL-4, and other molecules. Tfh cells are characterized by their expression of the chemoki...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 1999
ISSN: 0028-0836,1476-4687
DOI: 10.1038/35005503